منابع مشابه
DNA repair mechanisms and gametogenesis.
In mammals, there is a complex and intriguing relationship between DNA repair and gametogenesis. DNA repair mechanisms are involved not only in the repair of different types of DNA damage in developing germline cells, but also take part in the meiotic recombination process. Furthermore, the DNA repair mechanisms should tolerate mutations occurring during gametogenesis, to a limited extent. In t...
متن کاملDNA Repair Pathways and Mechanisms
Our cells are constantly exposed to insults from endogenous and exogenous agents that can introduce damage into our DNA and generate genomic instability. Many of these lesions cause structural damage to DNA and can alter or eliminate fundamental cellular processes, such as DNA replication or transcription. DNA lesions commonly include base and sugar modifications, singleand double-strand breaks...
متن کاملRepair mechanisms for oxidative DNA damage.
Reactive oxygen species are formed as by-products of mitochondrial aerobic respiration, as induced products upon exposure to certain environmental/exogenous agents (e.g. ionizing radiation), or as intended products during the immune response against invading foreign microbes. Although serving as essential signaling molecules in certain biological processes (e.g. during gene activation responses...
متن کاملMechanisms of human DNA repair: an update.
The human genome, comprising three billion base pairs coding for 30000-40000 genes, is constantly attacked by endogenous reactive metabolites, therapeutic drugs and a plethora of environmental mutagens that impact its integrity. Thus it is obvious that the stability of the genome must be under continuous surveillance. This is accomplished by DNA repair mechanisms, which have evolved to remove o...
متن کاملDNA Damage Response and Repair Mechanisms
The brochure accompanies the symposium and features the consortium and its members. Support by the European Community is gratefully acknowledged.
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ژورنال
عنوان ژورنال: Balıkesır Health Sciences Journal
سال: 2015
ISSN: 2146-9601,2147-2238
DOI: 10.5505/bsbd.2015.52523